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The observed pattern may indicate that constitutive expression of S

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Pyruvate is oxidized and decarboxylated by the pyruvate dehydrogenase complex (PDC) in mitochondrial matrix to produce acetyl-CoA, as the beginning of the following tricarboxylic acid cycle (TCA cycle)

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Copper(II) can kinetically trap arctic and Italian amyloid-40 as toxic oligomers, mimicking Cu(II) binding to wild-type amyloid-42: implications for familial Alzheimers disease

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Misfolded SOD1 pathology in sporadic amyotrophic lateral sclerosis

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Additionally, as a comparison, a model of the WT -SNAP protein was built with the alphafold3 server 26 and compared with the model generated with Modeller

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