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2014;9:e977746

Electrons are then transferred from the oxidoreductase flavoenzyme to the appropriate electron carrier, either oxidized thioredoxin (Trx-S 2 ) or glutathione disulfide (GSSG) converting them to reduced thioredoxin (Trx-[SH] 2 ) or glutathione (GSH), respectively

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In existing preclinical studies, Xiong and colleagues found that the co-expression of IL-7 and PH20 in GPC3-targeted CAR-T (G3CAR-7 20) demonstrated significant anti-tumor effects in both in vivo and in vitro experiments, making it a potential treatment for hepatocellular carcinoma [262]