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A study showed that Mthfr deficiency in mice exacerbated the PD-like symptoms in Mthfr +/ mice such as motor function impairments, elevated microglial activity in the substantia nigra, and increased oxidative stress in dorsal striatum suggesting that Mthfr deficiency heightens the vulnerability of substantia nigra and dorsal striatum to paraquat-induced damage [171]

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In the case of metallic NPs, especially gold NPs, citrate coating is the most commonly used coating material

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