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These substances can combine with proteins to form acetaldehyde adducts, triggering immune responses and exacerbating inflammation and fibrosis in ALD patients (Michalak et al., 2021)

6.7.4 Regional updates (Asia) A 2024 regional burden analysis (19902021) shows marked increases in incidence (+198%), prevalence (+284%), mortality (+111%), and DALYs (+144%) across Asia, emphasizing geographic variability relevant to projections (141)

Ogawa M

doi: 10.1080/13543776.2017.1254192 51

Allogeneic CAR T cells, also known as off-the-shelf CAR T cells (196, 197), are generated by genetically modifying T cells from healthy donors, enabling rapid therapeutic availability without the need to collect, process, and expand the patients own cells