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Glutathione and Nitrosoglutathione in Macrophage Defense Against Mycobacterium Tuberculosis

doi: 10.3389/fimmu.2025.1581385 Received 22 February 2025 Accepted 31 March 2025 Published 16 April 2025 Volume 16 - 2025 Edited by Eva Reali, University of Ferrara, Italy Reviewed by Anna Lisa Giuliani, University of Ferrara, Italy Nesimi Uludag, Namik Kemal University, Trkiye Updates Copyright 2025 Zhang, Pan, Sawa, Akaike and Matsunaga

CG, compound glycyrrhizin

In either case, health-damaging behaviors such as smoking, physical inactivity, and poor dietary habits significantly contribute to increased morbidity and mortality in affected populations

In contrast, the reversible (de-)glutathionylation reaction involves only the more N-terminal cysteine residue in the active site, and is thus referred to as the monothiol reaction mechanism