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We know that clogged coronary arteries can lead to heart attacks

Labelling of metcLip-1 in cells revealed a similar staining pattern to that of labelled cLip-1, showing colocalization with a lysosomal marker

Copper exacerbates vascular damage through this mechanism and may also stimulate immune responses in the vascular endothelium, increasing local inflammation and thereby raising the risk of ischemic stroke (228)