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Published animal studies reported that oral acetaminophen treatment of male animals at doses that are 1.2 times the MHDD and greater (based on a body surface area comparison) result in decreased testicular weights, reduced spermatogenesis, and reduced fertility

Moreover, IFN-/STAT1 pathway is regulated by facilitating the non-cytolytic virus clearance and modulating the neuronal excitability within neurons, thus contributing to enhance the immune surveillance (114)

The increased oxidative stress in neurons was partially attributed to the reduced expression of redox defense genes [179]

2.4 Estimation of glutathione-S-transferase (GST) GST enzyme activity was assayed spectrophotometrically at 340 nm following the method of Habig et al

Recently, efforts have focused on designing and developing fluorescent-based agents for disease diagnosis and treatment