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In neurons and astrocytes roxadustat provoked a HIF-1-dependent glucose metabolism reprogramming including elevation of glucose uptake, glycogen synthesis, glycolytic capacity, lactate production and lactate release, which enhanced the ischemic tolerance of astrocytes, but not neurons

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doi: 10.3389/fnut.2025.1696066 Received 31 August 2025 Revised 01 December 2025 Accepted 05 December 2025 Published 23 January 2026 Volume 12 - 2025 Edited by Jianmei Li, Nanjing Normal University, China Reviewed by Peng-Yu Zhong, Nanchong Central Hospital, China Uttam Khatri, The University of Texas at Austin, United States Updates Copyright 2026 Jin, Zhai, Bai, Hu, Yu, Sang, Wu and Hao

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