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The many causes of OH include drugs, neurogenic and nonneurogenic causes, cardiac pump failure, and venous pooling (Table I)

Table 1 Therapeutic strategies targeting ferroptosis and their mechanisms of action

10.1007/s00431-003-1171-5 42

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Further, mercury has been shown to directly alter neurotransmitter function by affecting the uptake and release of dopamine, norepinephrine and serotonin, preferentially inhibiting GABA A receptor subtypes and stimulating M 3 muscarinic acetylcholine receptors (Atchison and Hare, 1994

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