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employed in osteoarthritis and cartilage regeneration research Pigs Used for pharmacokinetic profiling and oral bioavailability studies Cynomolgus monkeys 9-month chronic toxicology studies via oral gavage Human subjects Approximately 900 participants across six clinical trials examining safety and efficacy Research Limitations & Regulatory Status Critical Gaps in Current Evidence Despite over 25 years of research and extensive clinical testing, AOD-9604 faces substantial evidence gaps that have prevented therapeutic development

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Others maintain the standard dose and inject systemically, allowing the peptide to distribute to both injury sites through circulation

Hematocrit and reticulocyte counts should be repeated daily from the fifth to seventh days of therapy, and then frequently until the hematocrit is normal