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Structural basis for rational design of inhibitors targetingTrypanosoma cruzisterol 14-demethylase: Two regions of the enzyme molecule potentiate its inhibition

Ijerph 16, 757

HIF-1 lies upstream of vascular endothelial growth factor (Hu et al., 2016), which itself is directly (or indirectly via HIF-1) induced by copper (Sen et al., 2002)