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However, one challenge of this study is that the modulator has many active ingredients, which makes it difficult to ascribe which is/are having the effect and thus the mechanism of action remains speculative

Vitamin B6 : Supports neurotransmitter function and helps convert food into energy

Additionally, the lack of sensation in the feet, often overlooked by patients, can lead to insensate injuries, falls, foot ulceration, and even amputation, underscoring the urgent need for early identification and intervention [2, 14,15,16]

SAM S-adenosyl-L-[methyl-3H] methionine PRMT3 activity assay A radiometric assay was performed by RBC using 100 M-5 nM SAH as an inhibitor positive control