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novel cancer therapeutics can also be assessed Well-characterized PDTX models represent an information-rich preclinical resource for analysis of drug activity, including novelnovel drug combinations, as well as predictive biomarker discovery The PDTX approach to modelling of specific cancer types could potentially reduce non-informative animal studies while providing a more-relevant system to test clinically directed hypotheses This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access 189,00 per year only 15,75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

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10 , R61 (2008)

HUVECs treated with ET-1-generated EMVs showed a higher release of interleukin (IL)6, IL-8, total NF-B p65, and active NF-B p65 expression than HUVECs treated with control EMVs

Prevention of oxaliplatin-related neurotoxicity by calcium and magnesium infusions: a retrospective study of 161 patients receiving oxaliplatin combined with 5-Fluorouracil and leucovorin for advanced colorectal cancer