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Altered genome-wide methylation in endometriosis

QRT-PCR validation of RNA-seq data To validate RNA-seq results, eight DEGs were examined by qRT-PCR, covering three functional categories: antioxidant defense ( GjAPX6 , GjGST6 , GjPOD11 , GjSOD1 ), calcium signaling ( GjABA1 , GjCML2 , GjCML6 ), and ion homeostasis ( GjSOS2 )

The exact structurefunction relationships and mechanistic differences among glutaredoxins that are active or inactive in standard enzyme assays have so far remained elusive despite numerous kinetic and structural studies

It is well known that silencing of tumor-suppressor genes is associated with the promoter-region hypermethylation, which can induce cell proliferation and over-growth, and ultimately lead to tumorigenesis