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Disruption in these localized immune defenses may initiate or amplify systemic inflammation and contribute to disease pathogenesis

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In a mouse model of OXA-induced liver injury, Robinson et al (10) observed that the expression levels of certain oxidative stress-related genes, including metallothionein 1 (Mt1), heme oxygenase 1 (HO1) and superoxide dismutase 3 (SOD3), were all upregulated

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