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An established concept is that PENs can serve as haptens to induce IgE through irreversibly forming drug-protein conjugates in vivo 2,9

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hEPO mRNAs were synthesized in vitro using T7RNA polymerase-mediated DNA-dependent RNA transcription where UTP was substituted with 100% N^methylpseudouracil (NIMPU), using linearized template for each UTR combination of Table 7

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