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Ion G Enhanced IGF-I Delivery to the Growth Plate and Accelerated Bone Elongation in a Mouse Model of Juvenile Obesity

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Persistent ERS in PT cells appears to bias cell fate toward a coupled apoptoticferroptotic axis, in which CHOP-associated death signaling and IRE1JNK-linked ferroptotic stress converge to deplete severely injured tubules while promoting the emergence of pro-inflammatory failed-repair states (215, 217, 218)