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Disulfiram (DSF) has been shown to protect mitochondrial integrity and improve outcomes in cerebral ischemia in mice by downregulating FDX1 to regulate Cu homeostasis, inhibiting the HSP70/TLR4/NLRP3 inflammatory pathway, and reducing oxidative stress (76)

10.3390/molecules27185925 Molecules 236 ZhangY.JiangY.YangX.HuangY.PanA.LiaoY

van Triest M, Bos JL (2004) Pull-down assays for guanoside 5-triphosphate-bound ras-like guanosine 5-triphosphatases

Gary found immense joy in the great outdoors, where the beauty of nature inspired his spirit