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200 Mutations in the gene encoding Cu/Zn SOD1 lead to abnormal mitochondrial activity, which is associated with a portion of ALS

Hc-hrg-2, a glutathione transferase gene, regulates heme homeostasis in the blood-feeding parasitic nematode Haemonchus contortus

however, the underlying causes have not been clearly elucidated

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CS is encoded by a single nuclear gene and is localized in the mitochondrial matrix where it functions as the first step of the TCA cycle, producing citric acid from acetyl-CoA and oxaloacetate (Fig