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We would certainly have crashed, and crashed hard, had not fellow Ars editor Lee Hutchinson provided incredible support

This is important for devices that need quick bursts of power

10.1111/cpr.13009 18 LongoN.FrigeniM.PasqualiM

The homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 2 (HERPUD1) in cultured HELA cells facilitate cytoprotective effects against oxidative stress by suppressing the inositol 1,4,5-triphosphate receptor and reducing the transfer of calcium ions from the endoplasmic reticulum to mitochondria [41]

At the same time, or due to higher mitochondrial activity, apoE4 is more inflammatory, which is characterized by chemokine production, immune cell adhesion and higher sensitivity of innate receptors to activation (Marottoli et al., 2021)