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Some of the preclinical assays described here were performed with the closely related precursor molecule, IMC-M113V RES , which differs from IMC-M113V by a single amino acid and demonstrates a similarly enhanced binding affinity to the cognate peptide HLA (pHLA)

The speed of onset is generally more rapid compared with the oral route, and for some drugs approaches that for the intravenous route

Prolonged stress significantly increases cortisol levels, which also have the potential to inhibit gonadotropin-releasing hormone (GnRH) and luteinizing hormone (LH) pulses (232), thus disrupting the formation and upkeep of CL

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