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Although several theories with empirical support tackle the point, the causes of BIPN are multifactorial and not fully understood, it remains a potentially persistent adverse event that can lead to long-term objective neurological dysfunction (Li et al., 2020), thereby reducing the quality of life, weakening physical function, causing delays or dose reductions in chemotherapy, and in some cases even interrupting treatment, imposing a huge economic burden (Selvy et al., 2021)

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Human use, largely based on user experiences, commonly involves subcutaneous or intramuscular injections of 200 to 500 micrograms per day, often divided into one or two doses

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Endocrine 27(2):119130 Antonelli M, Kushner I (2017) Its time to redefine inflammation