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To test its efficacy in the Drosophila model, we treated Drosophila concurrently with both NAC and APAP

Baron JM, Hller D, Schiffer R, Frankenberg S, Neis M, Merk HF, et al

Compensation between CSF1R+ macrophages and Foxp3+ Treg cells drives resistance to tumor immunotherapy

Another key point to assess is that murine models treated in this study were affected by liver-only metastases, with the liver being a particularly GSH-rich organ, that may represent a bias for evaluating this combination as an effective response in clinical practice, considering that melanoma metastases may occur in every other organ

Additionally, LDN was found to block toll-like receptor-4 expressed on immune cells in the CNS, which are responsible for triggering inflammatory responses