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In support of the NRF2 pathway being a potential target for the treatment of ALS, studies have shown that NRF2 overexpression in astrocytes provided neuroprotection against mutated SOD1-induced toxicity and increased the median survival of mutant SOD1 transgenic mice (Vargas et al., 2008

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10.1074/jbc.R115.648691 J

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Zhao YY, Yan Y, Li JX

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