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Simon, Massachusetts General Hospital Background: Eicosanoid lipid species have been associated with cardiovascular disease (CVD) and may be useful biomarkers to identify patients with metabolic syndrome at risk for incident CVD

Together, these enzyme systems shape the balance between activation and repression of chromatin states and stress-responsive pathways, and their activity is reflected in specific modification patterns under stress

It acts as a cofactor for enzymes that stabilize and crosslink collagen fibers, and it promotes the expression of genes that build collagen

Given the close association between NAFLD and metabolic dysfunction, a panel of experts proposed in 2020, not without some controversy, to rename this condition as metabolic-(dysfunction) associated fatty liver disease (4)

According to a previous study (85), the number of FAP + fibroblasts is significantly increased in the inflammatory synovium of collagen-induced arthritis (CIA) mice