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Eventually resulting in the demise of cells

Not only did both groups show significant improvements in bilirubin levels (a substance made in the liver during the normal process of breaking down red blood cells that a healthy liver regularly eliminates) months after the trial ended, they also saw a reduction of malondialdehyde, a marker of cell damage in the liver

Cuproptosis is based on the direct binding of copper ions to lipoylase proteins in the tricarboxylic acid cycle, leading to abnormal aggregation (174)