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Cell 80 , 263-278.e267 (2020)

When comparing GLP1-RA to insulin, there was no significant increase in the risk of major congenital malformations, with an adjusted relative risk of 0.95 for infants exposed to GLP1-RA

A reduction in the production of SCFAs, particularly butyrate, due to reduced populations of beneficial intestinal bacteria compromises the integrity of the intestinal barrier and promotes inflammation ( Table 1 ) [89, 90]