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A meta-analysis of 50,000 individuals given folic acid or placebo in cardiovascular or colon adenoma prevention trials found that folic acid supplementation did not substantially increase or decrease the incidence of site-specific cancer during the first 5 years of treatment

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The absence of regulatory oversight means users cannot be certain of what they are actually receiving, even if the product label claims to contain BPC-157

Split dosing offers no metabolic advantage and dilutes the fasted-state benefit