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Ann Transl Med (2022) 10:431

However, the disease remains a problem worldwide and causes tens of thousands Trusted Source of deaths annually, mostly in rural areas of Southeast Asia and Africa

For example, Astragalus polysaccharide (APS) was shown to inhibit the formation of the pre-metastatic niche in lung cancer by blocking the S1PR1/STAT3 signaling pathway, thereby preventing metastasis when used alongside standard treatment (143)

These findings are based on laboratory research, making FOXO4-DRI valuable for scientists exploring senolytic mechanisms