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A stock solution of collagen hydrogel at a 6 mg/mL concentration was prepared according to the manufacturers instructions and our recent studies [37]

Aplastic anemia can be hereditary, which a person would know about it early in life, or it can arise later in life as a result of other causes, such as the following: Exposure to common environmental toxins, such as pesticides, arsenic, and benzene Radiation and chemotherapy Medicines, including antibiotics Infectious diseases such as Epstein Barr Virus, HIV, or hepatitis Autoimmune conditions, lupus, and rheumatoid arthritis Premature destruction of red blood cells

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Arthritis developed in DBA/1J mice after intradermal injection of CII from day 20, with a rapid clinical progression (Figure 1a) that we monitored up to day 42