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Additionally, the vasodilatory effect of AMPK is mediated by eNOS, eventually leading to NO synthesis and endothelium-dependent coronary vasodilatation (Figure 5) (Shafique et al., 2013)

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To protect mitochondrial oxidative damage, several mitochondrial-targeted antioxidants have been developed and a great potential mitochondrial-targeted antioxidant is MitoQ