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Search strategy and inclusion criteria Relevant literatures published between 2013 and 2025 were retrieved from PubMed and Web of Science using the following search terms in title field: (Ginsenosides OR Panax OR Ginseng OR Ginseng saponin) AND (Depression OR Depressive disorder OR Depress OR Emotional disorder OR Psychological disorder OR Psychological distress OR Emotional distress OR Emotional stress)

One high-impact research framework

The bizarre part comes from the NIH funding what turned out to be a successful study and then being unwilling to fund a follow-up

The broad substrate specificity and abundance of ABC transporter proteins represent significant challenges to circumventing ABC-mediated MDR in vivo

this is because much of the extant evidence base is related to specific forms of Ginseng