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Aging of white matter in other brain diseases WM changes are also present in a number of other brain diseases, which can be grouped into genetic, demyelinative, infectious, inflammatory, toxic, metabolic, vascular, traumatic, neoplastic, hydrophilic, and neurodegenerative, as reviewed by Schmahmann et al (Schmahmann et al., 2008)

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Even the staunchest conventional physicians almost always recommend thyroid medication at this point