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Recent findings reveal that various molecules and pathways, including nuclear receptor coactivator 4, astrocyte-derived lactate, low-density lipoprotein receptor-related protein 1, and cGAS signaling, can influence cerebral IRI progression through unique lactylation mechanisms or by directly regulating overall lactylation levels [113,114,115,116]

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doi: 10.1007/s00213-021-05774-2 [DOI] [PubMed] [Google Scholar] 55.Charbogne P, Kieffer BL, Befort K

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