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Regulatory bodies such as the FDA and EMA have implemented rigorous guidelines to address the specific challenges encountered with pulmonary nanotherapeutics, ensuring comprehensive preclinical evaluations including pharmacokinetics, biodistribution, and toxicity studies, with particular attention to lung-specific endpoints like alveolar inflammation and mucociliary clearance ( 2+ release (Sun et al., 2023)

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High-resolution bimodal imaging and potent antibiotic/photodynamic synergistic therapy for osteomyelitis with a bacterial inflammation-specific versatile agent

In particular, immune modulatory effects of anti-CD38 antibodies during cancer therapy may be at least in part related to the decrease in CD38 NADase activity