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Then, the free energy released after ATP conversion to ADP and orthophosphate can be used to accumulate the transported substrates, controlling their movement between cellular compartments or intracellular/extracellular environments by modification of protein conformation

To directly test the ability of SNO-CoA to inhibit PDHC, we incubated purified PDHC with SNO-CoA without additional CoA or other NO donors

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IHC staining revealed that the GSTM3 level in the xenograft tumors were lower in the shGSTM3 group than that in the shNC group (Figures 5D,E)