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2 Shanghai Institute for Biomedical and Pharmaceutical Technologies, National Health Commission Key Laboratory of Reproduction Regulation, Shanghai, China

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By using the Electron Paramagnetic Resonance (EPR) spin trapping technique, the transitory formation of hydroxyl radical, which has a half life of 1 10 -9 sec at 37C, has been demonstrated [130]

Once into the brain, Vit B12 interacts with genes (LRRK2), proteins (synuclein and Lewy bodies), neurotransmitters (dopamine, Acetylcholine (Ach)) and metabolites that do impact on CNS hemostasis