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Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling

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Differentiation and culturing of neural progenitor cell WA09 (H9) human ESCs were maintained on matrigel-coated plates in E8 media 43 (all media and components are listed in Supplementary Tables 3 and 4)

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