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Most studies have chosen to target H3R, a presynaptic autoreceptor that regulates dopamine, acetylcholine, and histamine release via negative feedback, which has also been associated with other neurologic disorders such as Alzheimers disease and attention deficit hyperactive disorder (ADHD) [59,60]

Volosin M et al (2006) Interaction of survival and death signaling in basal forebrain neurons: roles of neurotrophins and proneurotrophins

TP53 germline mutations Germline mutation of TP53 in the heterozygous LOF form usually presents with a rare autosomally dominant genetic disease with a significantly increased risk of cancer development known as Li-Fraumeni syndrome (LFS)

Cupin variants as a macromolecular ligand library for stereoselective Michael addition of nitroalkanes

Triple drug therapy with gaba, sitagliptin, and omeprazole prevents type 1 diabetes onset and promotes its reversal in non-obese diabetic mice