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Inflammation-Immunity (Top Left): CP/CPPS triggers a local and systemic cytokine storm characterized by elevated pro-inflammatory cytokines (TNF-, IL-1, IL-6, IL-8), immune cell infiltration, Th17/Treg imbalance, and the production of antisperm antibodies (AsAb)

EtOH/POA also promotes calcium overload and nicotinamide adenine dinucleotide phosphate hydrogen (NADPH) oxidase activation

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Adverse Effects: Adverse effects of enoxaparin include diarrhea, nausea, anemia, hemorrhage, thrombocytopenia, hematoma, prosthetic cardiac valve thrombosis, increased liver function tests, atrial fibrillation, intracranial hemorrhage, epidural or spinal hematoma with paralysis, and pneumonia (5)

ROS can also play a role in cellular signaling pathways, triggering apoptosis, necrosis, or senescence depending on the cellular context