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Cysteine can also be produced independent of this pathway de novo through the transsulfuration pathway [10]

For instance, APPsw mice showed improved spatial memory and reduced cognitive deficits with chronic caffeine administration [14, 15]

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The 2-oxoglutarate carrier is S-nitrosylated in the spinal cord of G93A mutant hSOD1 mice resulting in disruption of mitochondrial glutathione transport