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10.1111/jog.14495 212 LiuM.QiuY.XueZ.WuR.LiJ.NiuX.et al (2020c)

The resultant accumulation of reactive oxygen species within erythrocytes leads to oxidation of hemoglobin (methemoglobin) and accumulation of denatured hemoglobin, which can result in hemolytic anemia, reduced arterial oxygen saturation on pulse oximetry, and impaired oxygen delivery to tissues from methemoglobin, often necessitating supplemental oxygen

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revealed that METTL14-dependent m6A modification downregulates HNF3C- expression, directly leading to sorafenib resistance [144]

While these treatments can help improve uneven pigmentation, they have a limited effect on overall skin whitening