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In contrast, the results of qRT-PCR revealed that the expression levels of key genes ( BECN1 , ATG3 , ATG4D , ATG5 , ATG12 , and SQSTM1 ) of the autophagy signal transduction pathway in HuOCSCs overexpressing ATF4 and treated with anisomycin were significantly higher than those in the control group (Figure 6B)

Lipid peroxidation is especially important in heart, brain, and nervous system cells

Given that microsatellite instability and somatic mutations have been identified in the lungs of PAH patients, DNA damage and repair dysregulation are strongly implicated as triggers for PAH progression [42, 43]

& Chulay, J

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