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The study continued or initiated metformin and titrated it up to 3000 mg (the maximum daily dose of metformin is higher in Hungary than in the United States)

The inner mitochondrial membrane is strictly impermeable to activated long-chain fatty acids (LCFAs), which possess 12 to 20 carbon atoms and represent the body's most dense and efficient source of potential energy

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doi: 10.3389/fnins.2015.00147 36 PeregoCFumagalliSDe SimoniM-G

STAT3 signaling controls cellular senescence and immunosenescence There is clear evidence that insulin/IGF-1 exposure can induce/augment the cellular senescence of different non-immune cells in several experimental conditions [144,145,146,147]