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In addition, dimorphic fungi such as Benjaminiella poitrasii , Mucor racemosus , and Schizophyllum commune have been reported to possess different NAD + - and NADPH-glutamate dehydrogenase activities when growing in the yeast and filamentous forms 14,15,16

In one clinical trial evaluating its use in both conditions, carboxytherapy was associated with statistically significant improvements in clinical scores, global assessments, and dermoscopic and digital trichoscopic parameters compared with the placebo [19]

Modulation of EMP-regulating pathways (AKT, AMPK, mTOR) provides additional therapeutic opportunities

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