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Cases of pneumomediastinum and esophageal rupture have been reported, as well as less common complications including rhabdomyolysis, vitamin K, B6, and B12 deficiency along with their associated symptomatology.[7] Acute tubular necrosis has been reported in association with severe volume depletion.[8] Further, hyperemesis gravidarum the most common indication for hospitalization in the first trimester, and is the second most common indication for hospitalization throughout pregnancy, second only to preterm labor.[8-10] With such a profound impact on quality of life, the treatment of nausea and vomiting of pregnancy (NVP) is a necessary component of any emergency medicine providers toolbox

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10.3390/ijms26115060 76 KonstantinidouF.BudaniM

Observed proteins with increased (red) and decreased (blue) ligandability changes