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However, data obtained from most experiments dealing with in vitro cell exposure to homocysteine are disappointing because the concentrations required are generally high and the effects generally have not been specific to homocysteine (Jacobsen, 1993)

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Furthermore, rodents do not easily develop addictive behaviour, naturally decrease alcohol consumption as acetaldehyde levels rise, metabolize alcohol quickly, have a high basal metabolic rate and demonstrate certain differences in the innate immune system 140

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