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Figure 11 Figure 12 4 Discussion Physiologically, the liver and kidneys are the most vital organs, performing numerous functions such as metabolism, detoxification, storage, and excretion of xenobiotics

Even before the identification of the HD gene and the development of transgenic models, researchers primarily relied on excitotoxic lesions in the striatum to simulate HD in animal studies (Ramaswamy et al., 2007)