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While metabolic reprogramming to glycolysis maintains short-term ATP supply, it leads to a long-term shortage of UDP-glucosamine (a substrate for matrix synthesis) and lactate accumulation, which can induce m collapse

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J Clin Investig 125(2):521538 Larson-Casey JL, Deshane JS, Ryan AJ, Thannickal VJ, Carter AB (2016) Macrophage Akt1 kinase-mediated mitophagy modulates apoptosis resistance and pulmonary fibrosis

Patients with immune-related adverse events received a significantly greater median number of immune checkpoint inhibitor doses than the patients without immune-related adverse events

The present review focuses on recent insights into the various biological functions of melatonin and bolds the importance of the agent as a valuable pharmacological tool once more