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Beyond its effects on the central nervous system, DSIP has been detected in peripheral organs, blood, cerebrospinal fluid, and even human breast milk, indicating a systemic physiological role

In addition to GLP-1, two more peptide hormones have shown potential for obesity treatment: glucose-dependent insulinotropic polypeptide (GIP) and amylin

While it is better studied in skin and wound healing contexts, there is emerging preclinical data suggesting GHK-Cu supports extracellular matrix remodeling and anti-inflammatory gene expression in gut tissue

The expanded approval was based on data from the Phase III EoE KIDS trial, where 66% of children who received the higher dose Dupixent at tiered dosing regimens experienced histological disease remission after 16 weeks of treatment, compared to just 3% in the placebo group, per the press release

These are generally mild to moderate and tend to improve as the body adjusts to each dose escalation step